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Article

Role of transforming growth factor-beta signaling in cancer.

Journal of the National Cancer Institute - 6 Sept 2000

de Caestecker M P, Piek E, Roberts A B

Abstract excerpt

Signaling from transforming growth factor-beta (TGF-beta) through its unique transmembrane receptor serine-threonine kinases plays a complex role in carcinogenesis, having both tumor suppressor and oncogenic activities. Tumor cells often escape from the antiproliferative effects of TGF-beta by mu...

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Source

Identifiers

PMID: 10974075
DOI: 10.1093/jnci/92.17.1388

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10974075-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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