Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TGF-β signalling and its role in cancer progression and metastasis.

Cancer metastasis reviews - 1 Dec 2012

Drabsch Yvette, ten Dijke Peter

Abstract excerpt

The transforming growth factor-β (TGF-β) system signals via protein kinase receptors and SMAD mediators to regulate a large number of biological processes. Alterations of the TGF-β signalling pathway are implicated in human cancer. Prior to tumour initiation and early during progression, TGF-β acts as a tumour suppressor; however, at later stages, it is often a tumour promoter. Knowledge about the mechanisms...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Progression
Share to Epithelial-Mesenchymal Transition
Share to Neoplasm Metastasis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Neoplasms

Share to Receptors, Transforming Growth Factor beta

Share to Smad Proteins

Share to Transforming Growth Factor beta

Share to Tumor Microenvironment

Source

Identifiers

PMID: 22714591
DOI: 10.1007/s10555-012-9375-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TGF-β signalling and its role in cancer progression and metastasis.PMID 22714591Read ↗

TGF-β signaling in cancerSemantic proximity Read ↗

TGF-β Signaling in Cancer: Mechanisms of Progression and Therapeutic TargetsSemantic proximity Read ↗

Exploring TGF-β Signaling in Cancer Progression: Prospects and Therapeutic StrategiesSemantic proximity Read ↗

The Role of TGF-β Signaling Pathways in Cancer and Its Potential as a Therapeutic TargetSemantic proximity Read ↗

Transforming growth factor β signaling pathway: A promising therapeutic target for cancerSemantic proximity Read ↗

Targeting the TGFβ pathway for cancer therapySemantic proximity Read ↗

Transforming growth factor‐β signaling: Tumorigenesis and targeting for cancer therapySemantic proximity Read ↗

Actions of TGF-beta as tumor suppressor and pro-metastatic factor in human cancer.Semantic proximity Read ↗

Molecular Pathways: Targeting the TGF-β Pathway for Cancer TherapySemantic proximity Read ↗

TGF<i>β</i>Signaling in Tumor Initiation, Epithelial-to-Mesenchymal Transition, and MetastasisSemantic proximity Read ↗

TGF‑β signaling: A complex role in tumorigenesis (Review)Semantic proximity Read ↗

TGF-β signaling and epithelial–mesenchymal transition in cancer progressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.