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Article

Analysis of her1 and her7 mutants reveals a spatio temporal separation of the somite clock module.

PloS one - 1 Jan 2012

Choorapoikayil Suma, Willems Bernd, Ströhle Peter, Gajewski Martin

Abstract excerpt

Somitogenesis is controlled by a genetic network consisting of an oscillator (clock) and a gradient (wavefront). The "hairy and Enhancer of Split"- related (her) genes act downstream of the Delta/Notch (D/N) signaling pathway, and are crucial components of the segmentation clock. Due to genome duplication events, the zebrafish genome, possesses two gene copies of the mouse Hes7 homologue: her1 and her7. To better...

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Identifiers

PMID: 22723933
DOI: 10.1371/journal.pone.0039073
PMCID: PMC3377618

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Analysis of her1 and her7 mutants reveals a spatio temporal separation of the somite clock module.PMID 22723933Read ↗

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Hairy/E(spl)-related (Her) genes are central components of the segmentation oscillator and display redundancy with the Delta/Notch signaling pathway in the formation of anterior segmental boundaries in the zebrafish.Semantic proximity Read ↗

Notch signalling and the synchronization of the somite segmentation clock.Semantic proximity Read ↗

tortuga refines Notch pathway gene expression in the zebrafish presomitic mesoderm at the post-transcriptional level.Semantic proximity Read ↗

Cooperative function of deltaC and her7 in anterior segment formation.Semantic proximity Read ↗

beamter/deltaC and the role of Notch ligands in the zebrafish somite segmentation, hindbrain neurogenesis and hypochord differentiation.Semantic proximity Read ↗

Tbx24, encoding a T-box protein, is mutated in the zebrafish somite-segmentation mutant fused somites.Semantic proximity Read ↗

Dynamic expression and essential functions of Hes7 in somite segmentation.Semantic proximity Read ↗

The long and short of it: somite formation in mice.Semantic proximity Read ↗

Notch signalling synchronizes the zebrafish segmentation clock but is not needed to create somite boundaries.Semantic proximity Read ↗

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