Article
Abolished tubuloglomerular feedback and increased plasma renin in adenosine A1 receptor-deficient mice.
American journal of physiology. Regulatory, integrative and comparative physiology - 1 Nov 2001
Brown R, Ollerstam A, Johansson B, Skøtt O, Gebre-Medhin S, Fredholm B, Persson A E
Abstract excerpt
The hypothesis that adenosine acting on adenosine A1 receptors (A1R) regulates several renal functions and mediates tubuloglomerular feedback (TGF) was examined using A1R knockout mice. We anesthetized knockout, wild-type, and heterozygous mice and measured glomerular filtration rate, TGF response using the stop-flow pressure (P(sf)) technique, and plasma renin concentration. The A1R knockout mice had an...
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