Article
Effect of carbonic anhydrase inhibition on GFR and renal hemodynamics in adenosine-1 receptor-deficient mice.
Pflugers Archiv : European journal of physiology - 1 Sept 2004
Hashimoto Seiji, Huang Yuning G, Castrop Hayo, Hansen Pernille B, Mizel Diane, Briggs Josie, Schnermann Jurgen
Abstract excerpt
The reduction of glomerular filtration rate (GFR) caused by inhibitors of carbonic anhydrase (CA) is thought to be initiated by activation of the tubuloglomerular feedback (TGF) mechanism. We determined the effect of the CA inhibitor benzolamide (Bz) on renal hemodynamics in adenosine-1 receptor (A1AR) knockout mice that have been shown previously to lack a TGF response. In A1AR(+/+) mice, Bz (150 microg plus 2...
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