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Article

Synthesis and secretion of renin in mice with induced genetic mutations.

Kidney international - 1 Mar 2012

Schnermann Jurgen, Briggs Josephine P

Abstract excerpt

The juxtaglomerular (JG) cell product renin is rate limiting in the generation of the bioactive octapeptide angiotensin II. Rates of synthesis and secretion of the aspartyl protease renin by JG cells are controlled by multiple afferent and efferent pathways originating in the CNS, cardiovascular system, and kidneys, and making critical contributions to the maintenance of extracellular fluid volume and arterial...

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Identifiers

PMID: 22258323
DOI: 10.1038/ki.2011.451
PMCID: PMC3482822

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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