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Article

A single nucleotide mutation in the mouse renin promoter disrupts blood pressure regulation.

The Journal of clinical investigation - 1 Mar 2008

Tanimoto Keiji, Sugiura Akiko, Kanafusa Sumiyo, Saito Tomoko, Masui Naoto, Yanai Kazuyuki, Fukamizu Akiyoshi

Abstract excerpt

Renin, a major regulatory component of the renin-angiotensin system, plays a pivotal role in regulating blood pressure and electrolyte homeostasis and is predominantly expressed in the kidney. Several cAMP-responsive elements have been identified within renin gene promoters. Here, we study how 2 such elements, renin proximal promoter element-2 (RP-2) and overlapping cAMP and negative regulatory elements (CNRE),...

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Identifiers

PMID: 18259612
DOI: 10.1172/JCI33824
PMCID: PMC2230662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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