Article
Close correlation of p53 mutation to microvascular invasion in hepatocellular carcinoma.
Journal of clinical gastroenterology - 1 Jan 2000
Park N H, Chung Y H, Youn K H, Song B C, Yang S H, Kim J A, Lee H C, Yu E, Lee Y S, Lee S G, Kim K W, Suh D J
Abstract excerpt
Mutation of p53 is a poor prognostic indicator of hepatocellular carcinoma (HCC). Although poor histologic differentiation of HCC has been associated with p53 mutations, the exact reasons for unfavorable clinical outcomes in patients with HCC remain to be clarified. In this study, we evaluate the association between p53 mutation and histopathologic features of HCCs, as well as tumor recurrences and survival. We...
Topics
- Carcinoma, Hepatocellular
- Female
- Genes, p53
- Humans
- Liver
- Liver Neoplasms
- Male
- Middle Aged
- Mutation
- Neoplasm Invasiveness
- Neoplasm Recurrence, Local