The clinical significance of p53 gene mutation in hepatocellular carcinomas from Japan.

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Article

The clinical significance of p53 gene mutation in hepatocellular carcinomas from Japan.

Hepatology (Baltimore, Md.) - 1 Dec 1995

Hayashi H, Sugio K, Matsumata T, Adachi E, Takenaka K, Sugimachi K

Abstract excerpt

To clarify the clinical significance of the mutation of p53 gene in hepatocellular carcinoma (HCC), 90 resected specimens from Japanese patients were assayed using a polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis. p53 mutations were detected in 25 cases (27....

Topics

Adult
Aged
Base Sequence
Carcinoma, Hepatocellular
DNA, Neoplasm
Female
Genes, p53
Humans
Japan
Liver Neoplasms
Male
Middle Aged
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Prognosis
Survival Rate

Source

Open in PubMed

Identifiers

PMID: 7489977

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7489977-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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