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Article

Immunohistochemical Determination of p53 Protein Overexpression for Predicting p53 Gene Mutations in Hepatocellular Carcinoma: A Meta-Analysis.

PloS one - 1 Jan 2016

Liu Jiangbo, Li Wei, Deng Miao, Liu Dechun, Ma Qingyong, Feng Xiaoshan

Abstract excerpt

BACKGROUND: Whether increased expression of the tumor suppressor protein p53 indicates a p53 gene mutation in hepatocellular carcinoma (HCC) remains unclear. We conducted a meta-analysis to determine whether p53 protein overexpression detected by immunohistochemistry (IHC) offers a diagnostic prediction for p53 gene mutations in HCC patients. METHODS: Systematic literature searches were conducted with an end date...

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Identifiers

PMID: 27428001
DOI: 10.1371/journal.pone.0159636
PMCID: PMC4948819

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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