Article
The expression of the mdm2 gene may be related to the aberration of the p53 gene in human hepatocellular carcinoma.
Journal of cancer research and clinical oncology - 1 Jan 1998
Qiu S J, Ye S L, Wu Z Q, Tang Z Y, Liu Y K
Abstract excerpt
The relationship between mdm2 gene expression and p53 gene mutation in hepatocellular carcinoma (HCC) and their correlation with the invasiveness of the disease were investigated in this study. Either the expression level of the mdm2 gene or the mutation rate of the p53 gene was higher in HCC tha...
Topics
- Adult
- Carcinoma, Hepatocellular
- DNA Primers
- Electrophoresis
- Female
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Humans
- Liver Neoplasms
- Male
- Mutation
- Neoplasm Invasiveness
- Neoplasm Proteins
- Nuclear Proteins
- Polymerase Chain Reaction
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-mdm2
- RNA-Directed DNA Polymerase