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Article

Association of immunohistochemical staining for p53 with metastatic progression and poor survival in patients with renal cell carcinoma.

Journal of the National Cancer Institute - 5 Oct 1994

Uhlman D L, Nguyen P L, Manivel J C, Aeppli D, Resnick J M, Fraley E E, Zhang G, Niehans G A

Abstract excerpt

BACKGROUND: Mutations of the p53 gene have been found in many types of human tumors. In some tumors, p53 gene mutations are associated with advanced disease and poor prognosis. There is wide variation in the reported incidence of p53 mutation in renal cell carcinoma, and its prognostic significance for this tumor is unknown. PURPOSE: This retrospective immunohistochemical study was designed to examine...

Topics

Adult
Aged
Aged, 80 and over
Carcinoma, Renal Cell
Chi-Square Distribution
Female
Genes, p53
Humans
Immunoenzyme Techniques
Kidney Neoplasms
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Mutation

Prognosis

Retrospective Studies

Survival Analysis

Source

Identifiers

PMID: 8089867
DOI: 10.1093/jnci/86.19.1470

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8089867-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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