Article
Prognosis in patients with hepatocellular carcinoma correlates to mutations of p53 and/or hMSH2 genes.
European journal of cancer (Oxford, England : 1990) - 1 Apr 2007
Yano Masatsugu, Hamatani Kiyohiro, Eguchi Hidetaka, Hirai Yuko, MacPhee Donald G, Sugino Keizo, Dohi Kiyohiko, Itamoto Toshiyuki, Asahara Toshimasa
Abstract excerpt
Association of gene alterations and prognosis has not fully been elucidated in hepatocellular carcinoma (HCC). To clarify the relationship between p53 and hMSH2 mutations and prognosis, we analysed these mutations in 83 HCC cases and assessed their association with various clinicopathological factors. The 3-year disease-free survival (DFS) or overall survival (OS) rates in HCC patients with p53 mutation and p53...
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