Article
Grade-of-membership sibpair linkage analysis maps IDDM11 to chromosome 14q24.3-q31.
Annals of human genetics - 1 Jul 2001
Corder E H, Woodbury M A, Manton K G, Field L L
Abstract excerpt
We demonstrate the use of Grade-of-membership (GoM) (Manton et al. 1994) for sibpair linkage analysis: GoM was used to map the IDDM11 locus to the region of chromosome 14q24.3 identified by Field et al. (1996). Haplotype groups were constructed from sib pair information on the number of shared alleles. The sample consisted of 578 sibling pairs found in 246 multiplex IDDM families. Both siblings were diabetic in...
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