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Joint Linkage and Association Analysis Using GENEHUNTER-MODSCORE with an Application to Familial Pancreatic Cancer.

Human heredity - 1 Jan 2024

Brugger Markus, Lutz Manuel, Müller-Nurasyid Martina, Lichtner Peter, Slater Emily P, Matthäi Elvira, Bartsch Detlef K, Strauch Konstantin

Abstract excerpt

INTRODUCTION: Joint linkage and association (JLA) analysis combines two disease gene mapping strategies: linkage information contained in families and association information contained in populations. Such a JLA analysis can increase mapping power, especially when the evidence for both linkage and association is low to moderate. Similarly, an association analysis based on haplotypes instead of single markers can...

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PMID: 38198765
DOI: 10.1159/000535840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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