A class of tests for linkage using affected pedigree members.

Article

A class of tests for linkage using affected pedigree members.

Biometrics - 1 Mar 1994

Whittemore A S, Halpern J

Abstract excerpt

We describe a class of nonparametric tests for linkage between a marker and a gene assumed to exist and to govern susceptibility to a disease. The tests are formed by assigning a score to each possible pattern of marker allele sharing (identity-by-descent) among affected pedigree members, and the...

Topics

Alleles
Biometry
Female
Genes, Dominant
Genes, Recessive
Genetic Linkage
Genetic Markers
Genetic Techniques
Humans
Lod Score
Male
Models, Genetic
Models, Statistical
Pedigree
Recombination, Genetic

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