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Article

Age of diagnosis-based linkage analysis in type 1 diabetes.

European journal of human genetics : EJHG - 1 Feb 2000

Paterson A D, Petronis A

Abstract excerpt

Genetic linkage studies of type 1 diabetes have produced a number of conflicting results, suggesting a high degree of locus heterogeneity in this disease. Approaches which model such heterogeneity will increase the power to fine map susceptibility loci. Here, using data from a genome scan of 356 affected sib pairs with type 1 diabetes, we performed heterogeneity analysis based on similarity of age at diagnosis of...

Topics

Age of Onset
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 4
Diabetes Mellitus, Type 1
Female
Genetic Heterogeneity
Genetic Linkage
Genetic Predisposition to Disease
Humans
Male
Matched-Pair Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microsatellite Repeats

Nuclear Family

Source

Identifiers

PMID: 10757648
DOI: 10.1038/sj.ejhg.5200420

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-10757648-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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