Article
An X-linked version of the affected-pedigree-member method of linkage analysis.
Human heredity - 1 Jan 2000
Weeks D E, Valappil T I, Schroeder M, Brown D L
Abstract excerpt
The affected-pedigree-member (APM) method of linkage analysis detects linkage by testing for increased marker similarity between affected individuals in a pedigree. Thus, the APM method poses a 'one-locus' question about the inheritance of the marker; it requires and makes no assumptions about the inheritance of the disease. It only requires that one be able to accurately determine who is affected. Since the APM...
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