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Article

Id2 is a target of the beta-catenin/T cell factor pathway in colon carcinoma.

The Journal of biological chemistry - 30 Nov 2001

Rockman S P, Currie S A, Ciavarella M, Vincan E, Dow C, Thomas R J, Phillips W A

Abstract excerpt

Activation of beta-catenin/T cell factor (TCF) transcription as a result of mutations in the adenomatous polyposis coli (APC) and/or beta-catenin genes occurs in the majority of colon tumors. An increasing number of genes, including c-myc and cyclin D1, have been implicated as targets of this pathway. We now report that the dominant negative helix-loop-helix regulator Id2 is also a target of the beta-catenin/TCF...

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Share to Adenoma
Share to Amino Acid Motifs
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colonic Neoplasms

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Source

Identifiers

PMID: 11572874
DOI: 10.1074/jbc.M107742200

Genes

APC
TCF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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