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Article

CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling.

Oncogene - 2 Sept 1999

da Costa L T, He T C, Yu J, Sparks A B, Morin P J, Polyak K, Laken S, Vogelstein B, Kinzler K W

Abstract excerpt

The majority of human colorectal cancers have elevated beta-catenin/TCF regulated transcription due to either inactivating mutations of the APC tumor suppressor gene or activating mutations of beta-catenin. Surprisingly, one commonly used colorectal cancer cell line was found to have intact APC and beta-catenin and no demonstrable beta-catenin/TCF regulated transcription. However, this line did possess a...

Read the complete abstract on PubMed

Topics

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Share to Transcriptional Activation
Share to Adenomatous Polyposis Coli Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to beta Catenin

Share to CDX2 Transcription Factor

Share to Cytoskeletal Proteins

Share to Genes, Tumor Suppressor

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Source

Identifiers

PMID: 10490837
DOI: 10.1038/sj.onc.1202872

Genes

APC
CDX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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