Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CDX2, a homeobox transcription factor, upregulates transcription of the p21/WAF1/CIP1 gene.

Oncogene - 11 Sept 2003

Bai Yun-Qing, Miyake Satoshi, Iwai Takehisa, Yuasa Yasuhito

Abstract excerpt

The CDX2 homeobox transcription factor plays key roles in intestinal development and homeostasis. CDX2 is downregulated during colorectal carcinogenesis, whereas overexpression of CDX2 results in growth inhibition and differentiation of colon carcinoma and intestinal cells. However, the means by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma
Share to CDX2 Transcription Factor
Share to Colonic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p21

Share to Cyclins

Share to Electrophoretic Mobility Shift Assay

Share to Homeodomain Proteins

Share to Up-Regulation

Source

Identifiers

PMID: 12970742
DOI: 10.1038/sj.onc.1206634

Genes

CDX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12970742-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CDX2, a homeobox transcription factor, upregulates transcription of the p21/WAF1/CIP1 gene.PMID 12970742Read ↗

Cdx2 Controls Expression of the Protocadherin Mucdhl, an Inhibitor of Growth and β-Catenin Activity in Colon Cancer CellsSemantic proximity Read ↗

Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2Semantic proximity Read ↗

Genome-wide analysis of CDX2 binding in intestinal epithelial cells (Caco-2).Semantic proximity Read ↗

Relationship of CDX2 Loss with Molecular Features and Prognosis in Colorectal CancerSemantic proximity Read ↗

Altered expression of CDX2 in colorectal cancersSemantic proximity Read ↗

CDX2 controls genes involved in the metabolism of 5-fluorouracil and is associated with reduced efficacy of chemotherapy in colorectal cancerSemantic proximity Read ↗

The role of CDX2 in intestinal homeostasis and inflammationSemantic proximity Read ↗

The clinical perspectives of CDX2 expression in colorectal cancer: a qualitative systematic review.Semantic proximity Read ↗

CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling.Semantic proximity Read ↗

CDX2 is involved in microRNA‑associated inflammatory carcinogenesis in gastric cancerSemantic proximity Read ↗

New insights into the functions and localization of the homeotic gene CDX2 in gastric cancer.Semantic proximity Read ↗

Different effects of the Cdx1 and Cdx2 homeobox genes in a murine model of intestinal inflammation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.