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Article

Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin.

International journal of cancer - 1 Oct 2002

Wang Hanlin L, Wang Julia, Xiao Shu-Yuan, Haydon Rex, Stoiber Debra, He Tong-Chuan, Bissonnette Marc, Hart John

Abstract excerpt

Mutations of the adenomatous polyposis coli tumor suppressor gene, or its downstream target beta-catenin, have been implicated in the initiation of most sporadic human colorectal epithelial neoplasms. These mutations, in turn, lead to aberrant nuclear accumulation of beta-catenin and subsequent activation of the beta-catenin/Tcf transcription factor complex. In vitro studies utilizing cultured human colon cancer...

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Source

Identifiers

PMID: 12209953
DOI: 10.1002/ijc.10630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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