Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human MUC2 mucin gene is transcriptionally regulated by Cdx homeodomain proteins in gastrointestinal carcinoma cell lines.

The Journal of biological chemistry - 19 Dec 2003

Mesquita Patrícia, Jonckheere Nicolas, Almeida Raquel, Ducourouble Marie-Paule, Serpa Jacinta, Silva Elisabete, Pigny Pascal, Silva Filipe Santos, Reis Celso, Silberg Debra, Van Seuningen Isabelle, David Leonor

Abstract excerpt

In intestinal metaplasia and 30% of gastric carcinomas, MUC2 intestinal mucin and the intestine-specific transcription factors Cdx-1 and Cdx-2 are aberrantly expressed. The involvement of Cdx-1 and Cdx-2 in the intestinal development and their role in transcription of several intestinal genes support the hypothesis that Cdx-1 and/or Cdx-2 play important roles in the aberrant intestinal differentiation program of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CDX2 Transcription Factor
Share to Gastrointestinal Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Homeodomain Proteins

Share to Mucin-2

Share to Mucins

Share to Trans-Activators

Share to Transcriptional Activation

Share to Transfection

Source

Identifiers

PMID: 14525978
DOI: 10.1074/jbc.M309019200

Genes

MUC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human MUC2 mucin gene is transcriptionally regulated by Cdx homeodomain proteins in gastrointestinal carcinoma cell lines.PMID 14525978Read ↗

Cdx2 Controls Expression of the Protocadherin Mucdhl, an Inhibitor of Growth and β-Catenin Activity in Colon Cancer CellsSemantic proximity Read ↗

CDX2 autoregulation in human intestinal metaplasia of the stomach: impact on the stability of the phenotypeSemantic proximity Read ↗

Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2Semantic proximity Read ↗

Cdx2 transcription factor regulates claudin‐3 and claudin‐4 expression during intestinal differentiation of gastric carcinomaSemantic proximity Read ↗

Forkhead box transcription factors Foxa1 and Foxa2 are important regulators of Muc2 mucin expression in intestinal epithelial cells.Semantic proximity Read ↗

Sox2 expression is maintained while gastric phenotype is completely lost in Cdx2-induced intestinal metaplastic mucosa.Semantic proximity Read ↗

Silencing of CDX2 expression in colon cancer via a dominant repression pathway.Semantic proximity Read ↗

Genome-wide analysis of CDX2 binding in intestinal epithelial cells (Caco-2).Semantic proximity Read ↗

CDX2 expression in the intestinal-type gastric epithelial neoplasia: frequency and significance.Semantic proximity Read ↗

CDX2 expression is increased in gastric cancers with less invasiveness and intestinal mucin phenotype.Semantic proximity Read ↗

Epigenetic silencing of CDX2 is a feature of squamous esophageal cancer.Semantic proximity Read ↗

The clinical perspectives of CDX2 expression in colorectal cancer: a qualitative systematic review.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.