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Article

Human MUC2 mucin gene is transcriptionally regulated by Cdx homeodomain proteins in gastrointestinal carcinoma cell lines.

The Journal of biological chemistry - 19 Dec 2003

Mesquita Patrícia, Jonckheere Nicolas, Almeida Raquel, Ducourouble Marie-Paule, Serpa Jacinta, Silva Elisabete, Pigny Pascal, Silva Filipe Santos, Reis Celso, Silberg Debra, Van Seuningen Isabelle, David Leonor

Abstract excerpt

In intestinal metaplasia and 30% of gastric carcinomas, MUC2 intestinal mucin and the intestine-specific transcription factors Cdx-1 and Cdx-2 are aberrantly expressed. The involvement of Cdx-1 and Cdx-2 in the intestinal development and their role in transcription of several intestinal genes sup...

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Source

Identifiers

PMID: 14525978
DOI: 10.1074/jbc.M309019200

Genes

MUC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14525978-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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