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Article

Identification of Trop-2 as an oncogene and an attractive therapeutic target in colon cancers

1 Feb 2008

Abstract excerpt

The cell surface protein Trop-2 is highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. However, whether Trop-2 is actively involved in tumorigenesis and whether its targeting for treatment would be...

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PMID: 18281513
DOI: 10.1158/1535-7163.mct-07-2003

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