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Article

Silencing of CDX2 expression in colon cancer via a dominant repression pathway.

The Journal of biological chemistry - 7 Nov 2003

Hinoi Takao, Loda Massimo, Fearon Eric R

Abstract excerpt

CDX2 is a caudal-related homeobox transcription factor whose expression in the adult is normally restricted to intestinal epithelium. Mice heterozygous for germ line Cdx2 inactivation develop intestinal polyps, and the lesions lack Cdx2 expression. Prior studies indicate some human colon carcinomas also lack CDX2 expression. To address the role of CDX2 defects in colon cancer development, we analyzed CDX2...

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Identifiers

PMID: 12947088
DOI: 10.1074/jbc.M307435200

Genes

CDX2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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