Suppression of inhibitor of differentiation 2, a target of mutant p53, is required for gain-of-function mutations.

Abstract excerpt

Overexpression of mutant p53 is a common theme in human tumors, suggesting a tumor-promoting gain-of-function for mutant p53. To elucidate whether and how mutant p53 acquires its gain-of-function, mutant p53 is inducibly knocked down in the SW480 colon cancer cell line, which contains mutant p53(R273H/P309S), and the MIA PaCa-2 pancreatic cancer cell line, which contains mutant p53(R248W). We found that knockdown...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Blotting, Northern
• Share to Chromatin Immunoprecipitation