Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation.

Cancer cell - 1 Mar 2002

Kolligs Frank T, Nieman Marvin T, Winer Ira, Hu Gang, Van Mater David, Feng Ying, Smith Ian M, Wu Rong, Zhai Yali, Cho Kathleen R, Fearon Eric R

Abstract excerpt

In many cancers, inactivation of the adenomatous polyposis coli (APC) or Axin tumor suppressor proteins or activating mutations in beta-catenin lead to elevated beta-catenin levels, enhanced binding of beta-catenin to T cell factor (TCF) proteins, and increased expression of TCF-regulated genes. We found that the gene for the basic helix-loop-helix transcription factor ITF-2 (immunoglobulin transcription...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Cytoskeletal Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphoid Enhancer-Binding Factor 1

Share to TCF Transcription Factors

Share to Transcription Factor 4

Share to Transcription Factor 7-Like 2 Protein

Share to Wnt Proteins

Share to Zebrafish Proteins

Source

Identifiers

PMID: 12086873
DOI: 10.1016/s1535-6108(02)00035-1

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation.PMID 12086873Read ↗

TCF transcription factors: molecular switches in carcinogenesis.Semantic proximity Read ↗

A combined bioinformatics and experimental approach identifies RMI2 as a Wnt/β-catenin signaling target gene related to hepatocellular carcinomaSemantic proximity Read ↗

Differential effect of NF‐κB activity on β‐catenin/Tcf pathway in various cancer cellsSemantic proximity Read ↗

Targeting the WNT/beta-catenin/TCF/LEF1 axis in solid and haematological cancers: Multiplicity of therapeutic options.Semantic proximity Read ↗

IRS1 regulation by Wnt/beta-catenin signaling and varied contribution of IRS1 to the neoplastic phenotype.Semantic proximity Read ↗

Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling.Semantic proximity Read ↗

Beta-catenin binds to the activation function 2 region of the androgen receptor and modulates the effects of the N-terminal domain and TIF2 on ligand-dependent transcription.Semantic proximity Read ↗

Id2 is a target of the beta-catenin/T cell factor pathway in colon carcinoma.Semantic proximity Read ↗

Targeted degradation of beta-catenin by chimeric F-box fusion proteins.Semantic proximity Read ↗

Wnt target genes and where to find themSemantic proximity Read ↗

Human Telomerase Reverse Transcriptase (hTERT) Is a Novel Target of the Wnt/β-Catenin Pathway in Human CancerSemantic proximity Read ↗

The oncogenic activation of beta-catenin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.