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Article

Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention.

Cancer research - 1 Nov 2002

Wilson Andrew J, Velcich Anna, Arango Diego, Kurland Amy R, Shenoy Shailesh M, Pezo Rossanna C, Levsky Jeffrey M, Singer Robert H, Augenlicht Leonard H

Abstract excerpt

Mutations in the adenomatous polyposis coli (APC) gene, which initiate almost all human colon cancers, directly target the proto-oncogene, c-myc, by elevating beta-catenin/T-cell factor (TCF) signaling. We have shown that agents ascribed chemopreventive activity for colon cancer in fact also stim...

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PMID: 12414619

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12414619-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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