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Article

In vivo function of a differentiation inhibitor, Id2.

IUBMB life - 1 Apr 2001

Yokota Y, Mori S, Narumi O, Kitajima K

Abstract excerpt

Cell differentiation is an essential process for the development of various cell types that constitute multicellular organisms. During development, the large family of factors bearing a helix-loop-helix (HLH) motif participates profoundly in this process and these factors serve as good experimental tools for investigating mechanisms underlying tissue-specific differentiation. The HLH family includes both positive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11569914
DOI: 10.1080/152165401753311744

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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In vivo function of a differentiation inhibitor, Id2.PMID 11569914Read ↗

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Id proteins in epithelial cells.Semantic proximity Read ↗

Proper expression of helix-loop-helix protein Id2 is important to chondrogenic differentiation of ATDC5 cells.Semantic proximity Read ↗

Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity.Semantic proximity Read ↗

Inhibitor of DNA binding in heart development and cardiovascular diseasesSemantic proximity Read ↗

A divalent ion is crucial in the structure and dominant-negative function of ID proteins, a class of helix-loop-helix transcription regulators.Semantic proximity Read ↗

Id2 haploinsufficiency in mice leads to congenital hydronephrosis resembling that in humans.Semantic proximity Read ↗

Forced expression of cyclin D1 does not compensate for Id2 deficiency in the mammary gland.Semantic proximity Read ↗

Id2 drives differentiation and suppresses tumor formation in the intestinal epithelium.Semantic proximity Read ↗

Inhibition of an Erythroid Differentiation Switch by the Helix-Loop-Helix Protein Id1Semantic proximity Read ↗

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