Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity.

The Journal of experimental medicine - 14 May 2007

Boos Markus D, Yokota Yoshifumi, Eberl Gerard, Kee Barbara L

Abstract excerpt

The Id2 transcriptional repressor is essential for development of natural killer (NK) cells, lymphoid tissue-inducing (LTi) cells, and secondary lymphoid tissues. Id2 was proposed to regulate NK and LTi lineage specification from multipotent progenitors through suppression of E proteins. We report that NK cell progenitors are not reduced in the bone marrow (BM) of Id2(-/-) mice, demonstrating that Id2 is not...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Transcription Factors
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Lineage

Share to Flow Cytometry

Share to Killer Cells, Natural

Share to Lymphoid Tissue

Share to Mice, Knockout

Share to Microscopy, Fluorescence

Source

Open in PubMed Open full text

Identifiers

PMID: 17452521
DOI: 10.1084/jem.20061959
PMCID: PMC2118569

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity.PMID 17452521Read ↗

The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development.Semantic proximity Read ↗

Balance between Id and E proteins regulates myeloid-versus-lymphoid lineage decisionsSemantic proximity Read ↗

High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice.Semantic proximity Read ↗

Augmenting E Protein Activity Impairs cDC2 Differentiation at the Pre-cDC Stage.Semantic proximity Read ↗

In vivo function of a differentiation inhibitor, Id2.Semantic proximity Read ↗

Forced expression of cyclin D1 does not compensate for Id2 deficiency in the mammary gland.Semantic proximity Read ↗

The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets.Semantic proximity Read ↗

Id3 and Id2 act as a dual safety mechanism in regulating the development and population size of innate-like γδ T cells.Semantic proximity Read ↗

Genome-Wide Analyses of Nkx2-1 Binding to Transcriptional Target Genes Uncover Novel Regulatory Patterns Conserved in Lung Development and TumorsSemantic proximity Read ↗

Ablation of cDC2 development by triple mutations within the Zeb2 enhancer.Semantic proximity Read ↗

Defective gene expression, S phase progression, and maturation during hematopoiesis in E2F1/E2F2 mutant mice.Semantic proximity Read ↗

IRF2 is required for development and functional maturation of human NK cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.