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Article

Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins.

Nature - 5 Oct 2000

Lasorella A, Noseda M, Beyna M, Yokota Y, Iavarone A

Abstract excerpt

In mammalian cells, Id proteins coordinate proliferation and differentiation. Id2 is a dominant-negative antagonist of basic helix-loop-helix transcription factors and proteins of the retinoblastoma (Rb) family. Here we show that Id2-Rb double knockout embryos survive to term with minimal or no d...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11034201
DOI: 10.1038/35036504

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11034201-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins.PMID 11034201Read ↗

Id2 mediates tumor initiation, proliferation, and angiogenesis in Rb mutant mice.Semantic proximity Read ↗

Loss of Id2 potentiates the tumorigenic effect of Rb inactivation in a mouse model of retinoblastoma.Semantic proximity Read ↗

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E Proteins and Id2 Converge on p57<sup>Kip2</sup> To Regulate Cell Cycle in Neural CellsSemantic proximity Read ↗

In vivo function of a differentiation inhibitor, Id2.Semantic proximity Read ↗

Id2 deficiency promotes metastasis in a mouse model of ocular cancer.Semantic proximity Read ↗

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RB, the conductor that orchestrates life, death and differentiation.Semantic proximity Read ↗

TBX2 blocks myogenesis and promotes proliferation in rhabdomyosarcoma cellsSemantic proximity Read ↗

A mechanism linking Id2-TGFβ crosstalk to reversible adaptive plasticity in neuroblastoma.Semantic proximity Read ↗

Id2 drives differentiation and suppresses tumor formation in the intestinal epithelium.Semantic proximity Read ↗

Id2 promotes the invasive growth of MCF-7 and SKOV-3 cells by a novel mechanism independent of dimerization to basic helix-loop-helix factorsSemantic proximity Read ↗

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