Article
Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins.
Nature - 5 Oct 2000
Lasorella A, Noseda M, Beyna M, Yokota Y, Iavarone A
Abstract excerpt
In mammalian cells, Id proteins coordinate proliferation and differentiation. Id2 is a dominant-negative antagonist of basic helix-loop-helix transcription factors and proteins of the retinoblastoma (Rb) family. Here we show that Id2-Rb double knockout embryos survive to term with minimal or no defects in neurogenesis and haematopoiesis, but they die at birth from severe reduction of muscle tissue. In...
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