Article
A divalent ion is crucial in the structure and dominant-negative function of ID proteins, a class of helix-loop-helix transcription regulators.
PloS one - 1 Jan 2012
Wong Marie Vivian, Jiang Sizun, Palasingam Paaventhan, Kolatkar Prasanna R
Abstract excerpt
Inhibitors of DNA binding and differentiation (ID) proteins, a dominant-negative group of helix-loop-helix (HLH) transcription regulators, are well-characterized key players in cellular fate determination during development in mammals as well as Drosophila. Although not oncogenes themselves, their upregulation by various oncogenic proteins (such as Ras, Myc) and their inhibitory effects on cell cycle proteins...
Topics
- Amino Acid Sequence
- Amino Acids
- Binding Sites
- Calcium
- Cations, Divalent
- Crystallography, X-Ray
- Electrophoretic Mobility Shift Assay
- Escherichia coli
- Humans
- Inhibitor of Differentiation Protein 2
- Inhibitor of Differentiation Proteins
- Models, Molecular
- Molecular Sequence Data