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Article

Id2 drives differentiation and suppresses tumor formation in the intestinal epithelium.

Cancer research - 15 Oct 2004

Russell Robert G, Lasorella Anna, Dettin Luis E, Iavarone Antonio

Abstract excerpt

Oncogenic signals elevate expression of Id2 in multiple tumor types. When deregulated, Id2 inactivates the tumor suppressor proteins retinoblastoma, p107, and p130. Here, we report a novel and unexpected tumor inhibitory function of Id2 in the intestinal epithelium. First, genetic ablation of Id2 in the mouse prevents differentiation and cell cycle arrest of enterocytes at the time of formation of the...

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Source

Identifiers

PMID: 15492237
DOI: 10.1158/0008-5472.CAN-04-2095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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