Article
Proper expression of helix-loop-helix protein Id2 is important to chondrogenic differentiation of ATDC5 cells.
The Biochemical journal - 1 May 2009
Yang Liu, Ma Xiaoyun, Lyone Anne, Zou Junhui, Blackburn Michael L, Pan Jing, Yang Dingqiao, Matsushita Hiroshi, Mei Bin, Zielinska-Kwiatkowska Anna, Chansky Howard A
Abstract excerpt
The process of chondrogenesis can be mimicked in vitro by insulin treatment of mouse ATDC5 chondroprogenitor cells. To identify novel factors that are involved in the control of chondrogenesis, we carried out a large-scale screening through retroviral insertion mutagenesis and isolated a fast-growing ATDC5 clone incapable of chondrogenic differentiation. Inverse-PCR analysis of this clone revealed that the...
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