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Article

ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis

15 Nov 2000

Abstract excerpt

The ubiquitously expressed family of ID helix-loop-helix (HLH) proteins function as dominant negative regulators of basic HLH (bHLH) transcriptional regulators that drive cell lineage commitment and differentiation in metazoa. Recent data from cell line and in vivo studies have implicated the functions of ID proteins in other cellular processes besides negative regulation of cell differentiation. ID proteins play...

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Identifiers

PMID: 11058077
DOI: 10.1242/jcs.113.22.3897

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