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Article

Id2 haploinsufficiency in mice leads to congenital hydronephrosis resembling that in humans.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Dec 2004

Aoki Yoshitaka, Mori Seiichi, Kitajima Kazuhito, Yokoyama Osamu, Kanamaru Hiroshi, Okada Kenichiro, Yokota Yoshifumi

Abstract excerpt

Congenital hydronephrosis is one of the most common anomalies found in humans and may cause renal failure in childhood. Half of the cases are due to obstruction at the ureteropelvic junction (UPJ). Here we report that mice lacking Id2, an inhibitor of basic helix-loop-helix (bHLH) transcription f...

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Source

Identifiers

PMID: 15569159
DOI: 10.1111/j.1365-2443.2004.00805.x

Genes

BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15569159-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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