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Article

SYD-2 Liprin-alpha organizes presynaptic active zone formation through ELKS.

Nature neuroscience - 1 Dec 2006

Dai Ya, Taru Hidenori, Deken Scott L, Grill Brock, Ackley Brian, Nonet Michael L, Jin Yishi

Abstract excerpt

A central event in synapse development is formation of the presynaptic active zone in response to positional cues. Three active zone proteins, RIM, ELKS (also known as ERC or CAST) and Liprin-alpha, bind each other and are implicated in linking active zone formation to synaptic vesicle release. Loss of function in Caenorhabditis elegans syd-2 Liprin-alpha alters the size of presynaptic specializations and...

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Identifiers

PMID: 17115037
DOI: 10.1038/nn1808

Genes

CAST

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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SYD-2 Liprin-alpha organizes presynaptic active zone formation through ELKS.PMID 17115037Read ↗

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Intramolecular regulation of presynaptic scaffold protein SYD-2/liprin-α.Semantic proximity Read ↗

The C2H2 zinc-finger protein SYD-9 is a putative posttranscriptional regulator for synaptic transmission.Semantic proximity Read ↗

Assembly of synaptic active zones requires phase separation of scaffold molecules.Semantic proximity Read ↗

The presynaptic dense projection of the Caenorhabditis elegans cholinergic neuromuscular junction localizes synaptic vesicles at the active zone through SYD-2/liprin and UNC-10/RIM-dependent interactions.Semantic proximity Read ↗

A Syd-1 homologue regulates pre- and postsynaptic maturation in Drosophila.Semantic proximity Read ↗

Genome-wide analysis reveals pathways important for the development and maturation of excitatory synaptic connections to GABAergic neurons.Semantic proximity Read ↗

Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission.Semantic proximity Read ↗

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