Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RIM and RIM-Binding Protein Localize Synaptic CaV2 Channels to Differentially Regulate Transmission in Neuronal Circuits.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 31 Jul 2024

Jánosi Barbara, Liewald Jana F, Seidenthal Marius, Yu Szi-Chieh, Umbach Simon, Redzovic Jasmina, Rentsch Dennis, Alcantara Ivan C, Bergs Amelie C F, Schneider Martin W, Shao Jiajie, Gottschalk Alexander

Abstract excerpt

At chemical synapses, voltage-gated Ca2+ channels (VGCCs) translate electrical signals into a trigger for synaptic vesicle (SV) fusion. VGCCs and the Ca2+ microdomains they elicit must be located precisely to primed SVs to evoke rapid transmitter release. Localization is mediated by Rab3-interacting molecule (RIM) and RIM-binding proteins, which interact and bind to the C terminus of the CaV2 VGCC α-subunit. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcium Channels

Share to Nerve Net

Share to Neuromuscular Junction

Share to Synapses

Share to Synaptic Transmission

Share to Synaptic Vesicles

Source

Open in PubMed Open full text

Identifiers

PMID: 38951038
DOI: 10.1523/JNEUROSCI.0535-22.2024
PMCID: PMC11293454

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RIM and RIM-Binding Protein Localize Synaptic CaV2 Channels to Differentially Regulate Transmission in Neuronal Circuits.PMID 38951038Read ↗

The Caenorhabditis elegans voltage-gated calcium channel subunits UNC-2 and UNC-36 and the calcium-dependent kinase UNC-43/CaMKII regulate neuromuscular junction morphology.Semantic proximity Read ↗

Spontaneous Vesicle Fusion Is Differentially Regulated at Cholinergic and GABAergic Synapses.Semantic proximity Read ↗

A post-docking role for active zone protein Rim.Semantic proximity Read ↗

A unique C2 domain at the C terminus of Munc13 promotes synaptic vesicle priming.Semantic proximity Read ↗

Direct interactions between C. elegans RAB-3 and Rim provide a mechanism to target vesicles to the presynaptic density.Semantic proximity Read ↗

RIM controls homeostatic plasticity through modulation of the readily-releasable vesicle pool.Semantic proximity Read ↗

[Contribution of synaptic release mechanisms to the building of sensory maps].Semantic proximity Read ↗

RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release.Semantic proximity Read ↗

RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses.Semantic proximity Read ↗

UNC-13 is required for synaptic vesicle fusion in C. elegans.Semantic proximity Read ↗

The presynaptic dense projection of the Caenorhabditis elegans cholinergic neuromuscular junction localizes synaptic vesicles at the active zone through SYD-2/liprin and UNC-10/RIM-dependent interactions.Semantic proximity Read ↗

A Trio of Active Zone Proteins Comprised of RIM-BPs, RIMs, and Munc13s Governs Neurotransmitter Release.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.