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Article

UNC-13 is required for synaptic vesicle fusion in C. elegans.

Nature neuroscience - 1 Nov 1999

Richmond J E, Davis W S, Jorgensen E M

Abstract excerpt

We analyzed the synaptic physiology of unc-13 mutants in the nematode C. elegans. Mutants of unc-13 had normal nervous system architecture, and the densities of synapses and postsynaptic receptors were normal at the neuromuscular junction. However, the number of synaptic vesicles at neuromuscular junctions was two- to threefold greater in unc-13 mutants than in wild-type animals. Most importantly, evoked release...

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Identifiers

PMID: 10526333
DOI: 10.1038/14755
PMCID: PMC2585767

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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UNC-13 is required for synaptic vesicle fusion in C. elegans.PMID 10526333Read ↗

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Open syntaxin overcomes synaptic transmission defects in diverse <i>C. elegans</i> exocytosis mutantsSemantic proximity Read ↗

A unique C2 domain at the C terminus of Munc13 promotes synaptic vesicle priming.Semantic proximity Read ↗

Tomosyn negatively regulates CAPS-dependent peptide release at Caenorhabditis elegans synapses.Semantic proximity Read ↗

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