Article
Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis.
Nature - 6 Sept 2001
Sharpless N E, Bardeesy N, Lee K H, Carrasco D, Castrillon D H, Aguirre A J, Wu E A, Horner J W, DePinho R A
Abstract excerpt
The cyclin-dependent kinase inhibitor p16INK4a can induce senescence of human cells, and its loss by deletion, mutation or epigenetic silencing is among the most frequently observed molecular lesions in human cancer. Overlapping reading frames in the INK4A/ARF gene encode p16INK4a and a distinct...
Topics
- 9,10-Dimethyl-1,2-benzanthracene
- Animals
- Carcinogens
- Cell Division
- Cell Transformation, Neoplastic
- Cells, Cultured
- Embryo, Mammalian
- Female
- Fibroblasts
- Gene Deletion
- Gene Targeting
- Genes, p16
- Genetic Predisposition to Disease
- Male
- Mice
- Mice, Knockout
- Neoplasms
- Proteins