Article
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF.
Cell - 28 Nov 1997
Kamijo T, Zindy F, Roussel M F, Quelle D E, Downing J R, Ashmun R A, Grosveld G, Sherr C J
Abstract excerpt
The INK4a tumor suppressor locus encodes p16INK4a, an inhibitor of cyclin D-dependent kinases, and p19ARF, an alternative reading frame protein that also blocks cell proliferation. Surprisingly, mice lacking p19ARF but expressing functional p16INK4a develop tumors early in life. Their embryo fibr...
Topics
- 3T3 Cells
- Animals
- Cell Division
- Cyclin-Dependent Kinase Inhibitor p16
- Exons
- Female
- G1 Phase
- Gene Deletion
- Gene Expression Regulation, Neoplastic
- Humans
- Kidney
- Leukemia, Erythroblastic, Acute
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Mutagenesis
- Neoplasms, Experimental