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Article

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF.

Cell - 28 Nov 1997

Kamijo T, Zindy F, Roussel M F, Quelle D E, Downing J R, Ashmun R A, Grosveld G, Sherr C J

Abstract excerpt

The INK4a tumor suppressor locus encodes p16INK4a, an inhibitor of cyclin D-dependent kinases, and p19ARF, an alternative reading frame protein that also blocks cell proliferation. Surprisingly, mice lacking p19ARF but expressing functional p16INK4a develop tumors early in life. Their embryo fibroblasts (MEFs) do not senesce and are transformed by oncogenic Ha-ras alone. Conversion of ARF+/+ or ARF+/- MEF strains...

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PMID: 9393858
DOI: 10.1016/s0092-8674(00)80452-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF.PMID 9393858Read ↗

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