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Article

The molecular balancing act of p16(INK4a) in cancer and aging.

Molecular cancer research : MCR - 1 Feb 2014

LaPak Kyle M, Burd Christin E

Abstract excerpt

p16(INK4a), located on chromosome 9p21.3, is lost among a cluster of neighboring tumor suppressor genes. Although it is classically known for its capacity to inhibit cyclin-dependent kinase (CDK) activity, p16(INK4a) is not just a one-trick pony. Long-term p16(INK4a) expression pushes cells to enter senescence, an irreversible cell-cycle arrest that precludes the growth of would-be cancer cells but also...

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Source

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Identifiers

PMID: 24136988
DOI: 10.1158/1541-7786.MCR-13-0350
PMCID: PMC3944093

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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