The INK4a/ARF locus in murine tumorigenesis.

doi:10.1093/carcin/21.5.865

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Article

The INK4a/ARF locus in murine tumorigenesis.

Carcinogenesis - 1 May 2000

Serrano M

Abstract excerpt

The INK4a/ARF locus is regarded as one of the most important anti-tumoral defenses that mammalian organisms possess. The characterization of its two gene products, p16(INK4a) and p19(ARF), has provided a great insight on the functioning of the tumor suppressors Rb and p53, respectively. Present e...

Topics

Alleles
Animals
Carrier Proteins
Cell Transformation, Neoplastic
Cyclin-Dependent Kinase Inhibitor p16
Genes, Tumor Suppressor
Genetic Predisposition to Disease
Mice
Mice, Transgenic

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