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Article

The differential impact of p16(INK4a) or p19(ARF) deficiency on cell growth and tumorigenesis.

Oncogene - 15 Jan 2004

Sharpless Norman E, Ramsey Matthew R, Balasubramanian Periasamy, Castrillon Diego H, DePinho Ronald A

Abstract excerpt

Mounting genetic evidence suggests that each product of the Ink4a/Arf locus, p16(INK4a) and p19(ARF), possesses tumor-suppressor activity (Kamijo et al., 1997; Krimpenfort et al., 2001; Sharpless et al., 2001a). We report the generation and characterization of a p19(ARF)-specific knockout allele (p19(ARF)-/-) and direct comparison with mice and derivative cells deficient for p16(INK4a), both p16(INK4a) and...

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PMID: 14724566
DOI: 10.1038/sj.onc.1207074

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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