Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Involvement of the INK4a/Arf gene locus in senescence.

Aging cell - 1 Jun 2003

Collins Carol J, Sedivy John M

Abstract excerpt

The INK4a/ARF locus encodes two proteins whose expression limits cellular proliferation. Whilst the biochemical activities of the two proteins appear very different, they both converge on regulating the retinoblastoma and p53 tumour suppressor pathways. Neither protein is required for normal development, but lack of either predisposes to the development of malignancy. Both proteins have also been implicated in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular Senescence
Share to Cyclin-Dependent Kinase Inhibitor p16
Share to Genes, p16

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

Share to Models, Genetic

Share to Retinoblastoma Protein

Share to Tumor Suppressor Protein p14ARF

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 12882406
DOI: 10.1046/j.1474-9728.2003.00048.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Involvement of the INK4a/Arf gene locus in senescence.PMID 12882406Read ↗

<i>Ink4‐Arf</i> locus in cancer and agingSemantic proximity Read ↗

The INK4a/ARF locus in murine tumorigenesis.Semantic proximity Read ↗

INK4a/ARF: a multifunctional tumor suppressor locus.Semantic proximity Read ↗

Anti‐aging activity of the <i>Ink4/Arf</i> locusSemantic proximity Read ↗

Dynamics of ARF regulation that control senescence and cancerSemantic proximity Read ↗

Ink4a/Arf expression is a biomarker of agingSemantic proximity Read ↗

p16INK4a and the control of cellular proliferative life spanSemantic proximity Read ↗

The molecular balancing act of p16(INK4a) in cancer and aging.Semantic proximity Read ↗

Biallelic mutations in p16(INK4a) confer resistance to Ras- and Ets-induced senescence in human diploid fibroblasts.Semantic proximity Read ↗

Molecular Regulation of Melanocyte SenescenceSemantic proximity Read ↗

Absence of p16 INK4a and truncation of ARF tumor suppressors in chickensSemantic proximity Read ↗

ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.