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Article

p16INK4a and the control of cellular proliferative life span

1 Jun 1999

Abstract excerpt

Normal somatic cells have a limited proliferative capacity in vitro: after a finite number of cell divisions they eventually enter a non-proliferative state referred to as senescence. Senescence is thought to be a major tumor suppressor mechanism, and many cancers contain cells that have escaped from senescence and become immortalized. The role of telomerase activation in immortalization is currently attracting...

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PMID: 10357768
DOI: 10.1093/carcin/20.6.921

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