Article
Role of the INK4a locus in tumor suppression and cell mortality.
Cell - 5 Apr 1996
Serrano M, Lee H, Chin L, Cordon-Cardo C, Beach D, DePinho R A
Abstract excerpt
The cell cycle inhibitor p16INK4a is inactivated in many human tumors and in families with hereditary melanoma and pancreatic cancer. Tumor-associated alterations in the INK4a locus may also affect the overlapping gene encoding p19ARF and the adjacent gene encoding p15I1NK4b, both negative regulators of cell proliferation. We report the phenotype of mice carrying a targeted deletion of the INK4a locus that...
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