Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice.

doi:10.1038/35092584

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Article

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice.

Nature - 6 Sept 2001

Krimpenfort P, Quon K C, Mooi W J, Loonstra A, Berns A

Abstract excerpt

CDKN2A (INK4a/ARF) is frequently disrupted in various types of human cancer, and germline mutations of this locus can confer susceptibility to melanoma and other tumours. However, because CDKN2A encodes two distinct cell cycle inhibitory proteins, p16INK4a and p14ARF (p19Arf in mice), the mechanism of tumour suppression by CDKN2A has remained controversial. Genetic disruption of Cdkn2a(p19Arf) (hereafter Arf)...

Topics

9,10-Dimethyl-1,2-benzanthracene
Animals
Carcinogens
Cell Transformation, Neoplastic
Cells, Cultured
Cyclin-Dependent Kinase Inhibitor p16
Embryo, Mammalian
Female
Fibroblasts
Gene Deletion
Genes, p16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, ras

Genetic Predisposition to Disease

Humans

Male

Melanoma, Experimental

Mice

Point Mutation

Source

Open in PubMed

Identifiers

PMID: 11544530
DOI: 10.1038/35092584

Genes

HRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-11544530-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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