Article
Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency.
Nature cell biology - 1 Jul 2008
Baker Darren J, Perez-Terzic Carmen, Jin Fang, Pitel Kevin S, Pitel Kevin, Niederländer Nicolas J, Jeganathan Karthik, Yamada Satsuki, Reyes Santiago, Rowe Lois, Hiddinga H Jay, Eberhardt Norman L, Terzic Andre, van Deursen Jan M
Abstract excerpt
Expression of p16(Ink4a) and p19(Arf) increases with age in both rodent and human tissues. However, whether these tumour suppressors are effectors of ageing remains unclear, mainly because knockout mice lacking p16(Ink4a) or p19(Arf) die early of tumours. Here, we show that skeletal muscle and fat, two tissues that develop early ageing-associated phenotypes in response to BubR1 insufficiency, have high levels of...
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