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Article

Expression of p16INK4a prevents cancer and promotes aging in lymphocytes

19 Jan 2011

Abstract excerpt

Previous authors have suggested that tumor suppressor expression promotes aging while preventing cancer, but direct experimental support for this cancer-aging hypothesis has been elusive. Here, by using somatic, tissue-specific inactivation of the p16(INK4a) tumor suppressor in murine T- or B-lymphoid progenitors, we report that ablation of p16(INK4a) can either rescue aging or promote cancer in a...

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Identifiers

PMID: 21245485
DOI: 10.1182/blood-2010-09-304402

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